{"id":15416,"date":"2022-12-22T11:14:40","date_gmt":"2022-12-22T10:14:40","guid":{"rendered":"https:\/\/kinderwunschaerztin.de\/leistungen\/dna-fragmentation\/"},"modified":"2026-10-06T14:44:55","modified_gmt":"2026-10-06T13:44:55","slug":"dna-fragmentation","status":"publish","type":"leistungen","link":"https:\/\/kinderwunschaerztin.de\/en\/services\/diagnostics\/dna-fragmentation\/","title":{"rendered":"DNA Frag\u00admen\u00adta\u00adtion"},"content":{"rendered":"\n
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What is DNA frag\u00admen\u00adta\u00adtion?<\/h2>\n\n\n\n

Sperm trans\u00adport pater\u00adnal genet\u00adic infor\u00adma\u00adtion to the egg cell. If there are breaks or dam\u00adage in the DNA of the sperm cells, this is referred to as increased DNA frag\u00admen\u00adta\u00adtion. <\/p>\n\n\n\n

An increased pro\u00adpor\u00adtion of frag\u00adment\u00aded sperm can influ\u00adence fer\u00adtil\u00adiza\u00adtion and ear\u00adly embry\u00adon\u00adic devel\u00adop\u00adment and may be asso\u00adci\u00adat\u00aded with a low\u00ader prob\u00ada\u00adbil\u00adi\u00adty of preg\u00adnan\u00adcy or an increased risk of mis\u00adcar\u00adriage.<\/p>\n\n\n\n

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When is a DNA frag\u00admen\u00adta\u00adtion test use\u00adful?<\/h3>\n\n\n\n

An exam\u00adi\u00adna\u00adtion of sperm DNA can mean\u00ading\u00adful\u00adly sup\u00adple\u00adment fer\u00adtil\u00adi\u00adty diag\u00adnos\u00adtics in var\u00adi\u00adous sit\u00adu\u00ada\u00adtions:<\/p>\n\n\n\n

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\n\"Logo\n\n\n\nIn cas\u00ades of unful\u00adfilled desire to have chil\u00addren despite an incon\u00adspic\u00adu\u00adous spermiogram<\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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Increased DNA frag\u00admen\u00adta\u00adtion can be present in both an abnor\u00admal and an incon\u00adspic\u00adu\u00adous spermiogram. Espe\u00adcial\u00adly when no preg\u00adnan\u00adcy occurs despite large\u00adly incon\u00adspic\u00adu\u00adous stan\u00addard diag\u00adnos\u00adtics, the exam\u00adi\u00adna\u00adtion can pro\u00advide addi\u00adtion\u00adal infor\u00adma\u00adtion, as DNA dam\u00adage is not vis\u00adi\u00adble in a clas\u00adsic spermiogram<\/a>. <\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\n\"Logo\n\n\n\nIn cas\u00ades of unsuc\u00adcess\u00adful IVF\/ICSI treat\u00adments<\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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If sev\u00ader\u00adal fer\u00adtil\u00adi\u00adty treat\u00adments have remained unsuc\u00adcess\u00adful, increased DNA frag\u00admen\u00adta\u00adtion of the sperm may be a pos\u00adsi\u00adble con\u00adtribut\u00ading cause. The exam\u00adi\u00adna\u00adtion can help to fur\u00adther assess sperm qual\u00adi\u00adty<\/a>. <\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\n\"Logo\n\n\n\nIn cas\u00ades of repeat\u00aded mis\u00adcar\u00adriages<\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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The exam\u00adi\u00adna\u00adtion of sperm DNA can also be use\u00adful in cas\u00ades of repeat\u00aded mis\u00adcar\u00adriages<\/a>. Increased DNA frag\u00admen\u00adta\u00adtion is asso\u00adci\u00adat\u00aded with impaired ear\u00adly embry\u00adon\u00adic devel\u00adop\u00adment and an increased risk of mis\u00adcar\u00adriage. <\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\n\"Logo\n\n\n\nIn the pres\u00adence of cer\u00adtain risk fac\u00adtors<\/strong><\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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For exam\u00adple, in the case of a varic\u00ado\u00adcele, high\u00ader pater\u00adnal age, inflam\u00adma\u00adtion, or sig\u00adnif\u00adi\u00adcant\u00adly restrict\u00aded sperm qual\u00adi\u00adty, a DNA frag\u00admen\u00adta\u00adtion analy\u00adsis can also be use\u00adful.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Pos\u00adsi\u00adble caus\u00ades of increased sperm DNA frag\u00admen\u00adta\u00adtion<\/h2>\n\n\n\n

DNA dam\u00adage to sperm can be pro\u00admot\u00aded by var\u00adi\u00adous fac\u00adtors. These include: <\/p>\n\n\n\n