{"id":15416,"date":"2022-12-22T11:14:40","date_gmt":"2022-12-22T10:14:40","guid":{"rendered":"https:\/\/kinderwunschaerztin.de\/leistungen\/dna-fragmentation\/"},"modified":"2026-10-06T14:44:55","modified_gmt":"2026-10-06T13:44:55","slug":"dna-fragmentation","status":"publish","type":"leistungen","link":"https:\/\/kinderwunschaerztin.de\/en\/services\/diagnostics\/dna-fragmentation\/","title":{"rendered":"DNA Frag\u00admen\u00adta\u00adti\u00adon"},"content":{"rendered":"\n
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What is DNA frag\u00admen\u00adta\u00adti\u00adon?<\/h2>\n\n\n\n

Sperm trans\u00adport pater\u00adnal gene\u00adtic infor\u00adma\u00adti\u00adon to the egg cell. If the\u00adre are breaks or dama\u00adge in the DNA of the sperm cells, this is refer\u00adred to as increased DNA frag\u00admen\u00adta\u00adti\u00adon. <\/p>\n\n\n\n

An increased pro\u00adpor\u00adti\u00adon of frag\u00admen\u00adted sperm can influence fer\u00adti\u00adliza\u00adti\u00adon and ear\u00adly embryo\u00adnic deve\u00adlo\u00adp\u00adment and may be asso\u00adcia\u00adted with a lower pro\u00adba\u00adbi\u00adli\u00adty of pregnan\u00adcy or an increased risk of mis\u00adcar\u00adria\u00adge.<\/p>\n\n\n\n

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When is a DNA frag\u00admen\u00adta\u00adti\u00adon test useful?<\/h3>\n\n\n\n

An exami\u00adna\u00adti\u00adon of sperm DNA can meaningful\u00adly sup\u00adple\u00adment fer\u00adti\u00adli\u00adty dia\u00adgno\u00adstics in various situa\u00adtions:<\/p>\n\n\n\n

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\n\"Logo\n\n\n\nIn cases of unful\u00adfil\u00adled desi\u00adre to have child\u00adren despi\u00adte an incon\u00adspi\u00adcuous sper\u00admio\u00adgram<\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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Increased DNA frag\u00admen\u00adta\u00adti\u00adon can be pre\u00adsent in both an abnor\u00admal and an incon\u00adspi\u00adcuous sper\u00admio\u00adgram. Espe\u00adci\u00adal\u00adly when no pregnan\u00adcy occurs despi\u00adte lar\u00adge\u00adly incon\u00adspi\u00adcuous stan\u00addard dia\u00adgno\u00adstics, the exami\u00adna\u00adti\u00adon can pro\u00advi\u00adde addi\u00adtio\u00adnal infor\u00adma\u00adti\u00adon, as DNA dama\u00adge is not visi\u00adble in a clas\u00adsic sper\u00admio\u00adgram<\/a>. <\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\n\"Logo\n\n\n\nIn cases of unsuc\u00adcessful IVF\/ICSI tre\u00adat\u00adments<\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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If seve\u00adral fer\u00adti\u00adli\u00adty tre\u00adat\u00adments have remain\u00aded unsuc\u00adcessful, increased DNA frag\u00admen\u00adta\u00adti\u00adon of the sperm may be a pos\u00adsi\u00adble con\u00adtri\u00adbu\u00adting cau\u00adse. The exami\u00adna\u00adti\u00adon can help to fur\u00adther assess sperm qua\u00adli\u00adty<\/a>. <\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\n\"Logo\n\n\n\nIn cases of repea\u00adted mis\u00adcar\u00adri\u00ada\u00adges<\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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The exami\u00adna\u00adti\u00adon of sperm DNA can also be useful in cases of repea\u00adted mis\u00adcar\u00adri\u00ada\u00adges<\/a>. Increased DNA frag\u00admen\u00adta\u00adti\u00adon is asso\u00adcia\u00adted with impai\u00adred ear\u00adly embryo\u00adnic deve\u00adlo\u00adp\u00adment and an increased risk of mis\u00adcar\u00adria\u00adge. <\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\n\"Logo\n\n\n\nIn the pre\u00adsence of cer\u00adtain risk fac\u00adtors<\/strong><\/strong><\/span>\n\n\n\n<\/svg><\/span><\/svg><\/span><\/span>\n<\/div>\n\n\n\n
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For exam\u00adp\u00adle, in the case of a vari\u00adco\u00adce\u00adle, hig\u00adher pater\u00adnal age, inflamm\u00ada\u00adti\u00adon, or signi\u00adfi\u00adcant\u00adly rest\u00adric\u00adted sperm qua\u00adli\u00adty, a DNA frag\u00admen\u00adta\u00adti\u00adon ana\u00adly\u00adsis can also be useful.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Pos\u00adsi\u00adble cau\u00adses of increased sperm DNA frag\u00admen\u00adta\u00adti\u00adon<\/h2>\n\n\n\n

DNA dama\u00adge to sperm can be pro\u00admo\u00adted by various fac\u00adtors. The\u00adse include: <\/p>\n\n\n\n