{"id":15445,"date":"2026-02-18T11:00:11","date_gmt":"2026-02-18T10:00:11","guid":{"rendered":"https:\/\/kinderwunschaerztin.de\/leistungen\/picsi\/"},"modified":"2026-10-06T15:01:08","modified_gmt":"2026-10-06T14:01:08","slug":"picsi","status":"publish","type":"leistungen","link":"https:\/\/kinderwunschaerztin.de\/en\/services\/treatments\/picsi\/","title":{"rendered":"PICSI"},"content":{"rendered":"\n
\n
\n

What is PICSI?<\/h2>\n\n\n\n

PICSI (Phy\u00adsio\u00adlo\u00adgi\u00adcal Intra\u00adcy\u00adto\u00adplas\u00admic Sperm Injec\u00adtion) is an addi\u00adtio\u00adnal method of sperm sel\u00adec\u00adtion as part of ICSI<\/a>. While in con\u00adven\u00adtio\u00adnal ICSI sperm are sel\u00adec\u00adted pri\u00adma\u00adri\u00adly based on moti\u00adli\u00adty and appearance (mor\u00adpho\u00adlo\u00adgy), PICSI also takes into account their abili\u00adty to bind to hyalu\u00adro\u00adnic acid.<\/p>\n\n\n\n

Hyalu\u00adro\u00adnic acid is a natu\u00adral com\u00adpo\u00adnent of the envi\u00adron\u00adment sur\u00adroun\u00adding the egg cell. A sperm cell\u2019s abili\u00adty to bind to it deve\u00adlo\u00adps as it matures and is the\u00adr\u00ade\u00adfo\u00adre con\u00adside\u00adred a bio\u00adlo\u00adgi\u00adcal mar\u00adker of matu\u00adri\u00adty. In PICSI, sperm are pla\u00adced in a spe\u00adcial cul\u00adtu\u00adre dish con\u00adtai\u00adning hyalu\u00adro\u00adnic acid. Sperm that bind to it can then be spe\u00adci\u00adfi\u00adcal\u00adly sel\u00adec\u00adted for ICSI. <\/p>\n\n\n\n

The method is the\u00adr\u00ade\u00adfo\u00adre based on a bio\u00adlo\u00adgi\u00adcal mecha\u00adnism that also plays a role in natu\u00adral fer\u00adti\u00adliza\u00adti\u00adon. Howe\u00adver, this does not mean that PICSI gene\u00adral\u00adly leads to bet\u00adter tre\u00adat\u00adment out\u00adco\u00admes. Lar\u00adge stu\u00addies have so far shown no clear advan\u00adta\u00adge over con\u00adven\u00adtio\u00adnal ICSI in terms of pregnan\u00adcy or live birth rates. The\u00adre are, howe\u00adver, indi\u00adca\u00adti\u00adons of a lower mis\u00adcar\u00adria\u00adge rate; whe\u00adther cer\u00adtain pati\u00adent groups bene\u00adfit in par\u00adti\u00adcu\u00adlar has not yet been con\u00adclu\u00adsi\u00adve\u00adly cla\u00adri\u00adfied. <\/p>\n\n\n\n

For this reason, we do not use PICSI rou\u00adti\u00adne\u00adly, but assess indi\u00advi\u00addu\u00adal\u00adly whe\u00adther the addi\u00adtio\u00adnal sperm sel\u00adec\u00adtion may be appro\u00adpria\u00adte based on your fin\u00addings and pre\u00advious tre\u00adat\u00adments.<\/p>\n\n\n\n

When is PICSI useful?<\/h3>\n\n\n\n

PICSI is not rou\u00adti\u00adne\u00adly recom\u00admen\u00added for every ICSI tre\u00adat\u00adment. For most pati\u00adents, no clear advan\u00adta\u00adge over con\u00adven\u00adtio\u00adnal ICSI has yet been demons\u00adtra\u00adted in terms of pregnan\u00adcy or live birth rates. Howe\u00adver, stu\u00addies indi\u00adca\u00adte a lower mis\u00adcar\u00adria\u00adge rate, and in cer\u00adtain abnor\u00adma\u00adli\u00adties of sperm qua\u00adli\u00adty<\/a>, addi\u00adtio\u00adnal sperm sel\u00adec\u00adtion may be con\u00adside\u00adred on an indi\u00advi\u00addu\u00adal basis. <\/p>\n\n\n\n

PICSI may be con\u00adside\u00adred, for exam\u00adp\u00adle, in cases of:<\/strong><\/p>\n\n\n\n