When pain or bleed­ing occurs in ear­ly preg­nan­cy, it can have many caus­es. One of these is an ectopic preg­nan­cy (tubal preg­nan­cy), in which the preg­nan­cy devel­ops out­side the uterus in the fal­lop­i­an tube. It should be detect­ed and treat­ed ear­ly, as it can lead to a rup­ture of the fal­lop­i­an tube and inter­nal bleed­ing as it pro­gress­es.

As a fer­til­i­ty cen­ter, we also sup­port women in the event of abnor­mal­i­ties in ear­ly preg­nan­cy and with ques­tions regard­ing fur­ther desire to have chil­dren. In this guide, we explain which signs can indi­cate an ectopic preg­nan­cy, how the diag­no­sis is made, how the ectopic preg­nan­cy is treat­ed, and what it means for a lat­er desire to have chil­dren.

What is an ectopic preg­nan­cy?

In an ectopic preg­nan­cy, the fer­til­ized egg does not implant in the uter­ine cav­i­ty, but in the fal­lop­i­an tube. It is thus the most com­mon form of a so-called extrauter­ine preg­nan­cy, i.e., a preg­nan­cy out­side the uterus. Ectopic preg­nan­cies account for about 1–2% of all preg­nan­cies.

The risk may be increased in women with:

  • A pre­vi­ous ectopic preg­nan­cy
  • Pre­vi­ous inflam­ma­tion in the pelvic area
  • Endometrio­sis
  • Pre­vi­ous chlamy­dia infec­tions
  • Pre­vi­ous sur­gi­cal inter­ven­tions
  • Smok­ing

How­ev­er, many ectopic preg­nan­cies also occur with­out known risk fac­tors.

After a pre­vi­ous ectopic preg­nan­cy, the risk of recur­rence for anoth­er ectopic preg­nan­cy is increased. The mag­ni­tude is stat­ed to be about 7–10%; nev­er­the­less, the prob­a­bil­i­ty that a nor­mal preg­nan­cy will occur in the uterus dur­ing a sub­se­quent preg­nan­cy is sig­nif­i­cant­ly high­er.

After sev­er­al pre­vi­ous ectopic preg­nan­cies, the risk increas­es sig­nif­i­cant­ly fur­ther and can be about 25–30% or more after two ectopic preg­nan­cies.

Woman with lower abdominal pain due to an ectopic pregnancy

Symp­toms

Typ­i­cal symp­toms and first signs (5th to 7th week of preg­nan­cy)

An ectopic preg­nan­cy can ini­tial­ly pro­ceed entire­ly with­out symp­toms. Symp­toms often only appear dur­ing the course of ear­ly preg­nan­cy and can vary great­ly in sever­i­ty.

Pos­si­ble signs include:

  • One-sided or increas­ing low­er abdom­i­nal pain
  • Spot­ting or unusu­al vagi­nal bleed­ing
  • Dizzi­ness, weak­ness, or cir­cu­la­to­ry prob­lems
  • Pain dur­ing bow­el move­ments or uri­na­tion can also occur

One should be par­tic­u­lar­ly atten­tive to the com­bi­na­tion of a pos­i­tive preg­nan­cy test, pain, and bleed­ing.

Impor­tant: If an ectopic preg­nan­cy is sus­pect­ed, a gyne­co­log­i­cal eval­u­a­tion should be car­ried out prompt­ly. In the event of severe pain or cir­cu­la­to­ry prob­lems, imme­di­ate med­ical eval­u­a­tion is nec­es­sary.

The fol­low­ing applies: “Even if an ectopic preg­nan­cy is only sus­pect­ed, a prompt eval­u­a­tion is always very impor­tant.”

Preg­nant despite bleed­ing? Why a peri­od is not an all-clear sig­nal

Bleed­ing can also occur in ear­ly preg­nan­cy. It can have very dif­fer­ent caus­es and can­not be reli­ably cat­e­go­rized based on col­or or inten­si­ty alone.

Pos­si­ble caus­es include, for exam­ple:

  • Bleed­ing in a healthy, intact ear­ly preg­nan­cy
  • A small hematoma
  • Con­tact bleed­ing, for exam­ple after sex­u­al inter­course
  • An impend­ing mis­car­riage
  • An ectopic preg­nan­cy

Bleed­ing can also occur with an ectopic preg­nan­cy and be mis­tak­en for men­stru­a­tion.

Our advice: If you have a pos­i­tive preg­nan­cy test and bleed­ing or pain occurs at the same time, you should seek med­ical advice quick­ly.

Modern practice and treatment room at the fertility center

Diag­nos­tics in ear­ly preg­nan­cy – when to see a doc­tor?

In the event of a pos­i­tive preg­nan­cy test and simul­ta­ne­ous symp­toms such as low­er abdom­i­nal pain or bleed­ing, a gyne­co­log­i­cal eval­u­a­tion should be car­ried out prompt­ly. This applies par­tic­u­lar­ly if risk fac­tors for an ectopic preg­nan­cy are already known.
For diag­nos­tics, we com­bine trans­vagi­nal ultra­sound with fol­low-up checks of the preg­nan­cy hor­mone hCG. The deci­sive fac­tor is not a sin­gle val­ue, but the joint assess­ment of symp­toms, ultra­sound find­ings, and hCG pro­gres­sion. This usu­al­ly allows for ear­ly detec­tion of whether the preg­nan­cy is devel­op­ing reg­u­lar­ly in the uterus or whether fur­ther checks are nec­es­sary.

Treat­ment of an ectopic preg­nan­cy

Treat­ment depends on your indi­vid­ual sit­u­a­tion, the symp­toms, the ultra­sound find­ings, and the pro­gres­sion of the preg­nan­cy hor­mone hCG.

Expec­tant man­age­ment
In the case of very ear­ly, sta­ble find­ings and already declin­ing hCG, close mon­i­tor­ing can be car­ried out in select­ed cas­es to see if the preg­nan­cy regress­es on its own.

Med­ical treat­ment with methotrex­ate
In the case of a reli­ably diag­nosed, non-rup­tured ectopic preg­nan­cy, methotrex­ate can be used under cer­tain con­di­tions. The med­ica­tion inhibits the fur­ther devel­op­ment of the preg­nan­cy tis­sue. Sub­se­quent­ly, reg­u­lar hCG checks are nec­es­sary.

Sur­gi­cal treat­ment
Surgery is nec­es­sary, in par­tic­u­lar, in the event of severe pain, cir­cu­la­to­ry insta­bil­i­ty, sus­pi­cion of a rup­ture, or cer­tain ultra­sound find­ings. If pos­si­ble, the pro­ce­dure is per­formed min­i­mal­ly inva­sive­ly as part of a laparoscopy.

When is a new preg­nan­cy pos­si­ble again?

After an ectopic preg­nan­cy, a new preg­nan­cy is pos­si­ble in most cas­es. When you can try to get preg­nant again depends on how the ectopic preg­nan­cy was treat­ed and how well you have recov­ered phys­i­cal­ly and emo­tion­al­ly.

After treat­ment with methotrex­ate, it is rec­om­mend­ed to wait at least three months before a new preg­nan­cy. Methotrex­ate inter­feres with folic acid metab­o­lism and can harm an ear­ly preg­nan­cy.

After sur­gi­cal treat­ment, the rec­om­mend­ed inter­val depends on the heal­ing process and your indi­vid­ual sit­u­a­tion.

HyCoSy exam­i­na­tion

After an ectopic preg­nan­cy, it may be use­ful to check the paten­cy of the fal­lop­i­an tubes if there is a renewed desire to have chil­dren – espe­cial­ly if there are risk fac­tors for dam­age to the fal­lop­i­an tubes or if preg­nan­cy is tak­ing a long time to occur.

A HyCoSy/HyFoSy exam­i­na­tion allows for a gen­tle assess­ment of whether one or both fal­lop­i­an tubes are patent, with­out the use of X‑rays. The exam­i­na­tion is per­formed via ultra­sound and can usu­al­ly be car­ried out with­out anes­the­sia.

It is impor­tant to note: HyCoSy shows whether a fal­lop­i­an tube is open, but it can­not reli­ably assess how well its func­tion actu­al­ly is or whether there are fin­er changes in the fal­lop­i­an tube lin­ing.

To the fal­lop­i­an tube check

Well-sup­port­ed for a renewed desire to have chil­dren

After an ectopic preg­nan­cy, ques­tions often arise regard­ing fur­ther fam­i­ly plan­ning and a pos­si­ble new preg­nan­cy. In our fer­til­i­ty cen­ter, we take the time to cat­e­go­rize and dis­cuss your his­to­ry and exist­ing find­ings and to deter­mine which exam­i­na­tions or next steps may be use­ful.

Our expe­ri­enced fer­til­i­ty doc­tors will advise you in an under­stand­able and per­son­al man­ner – with a view to your med­ical sit­u­a­tion and your ques­tions.

Fre­quent­ly asked ques­tions about ectopic preg­nan­cy

When do you notice an ectopic preg­nan­cy?

An ectopic preg­nan­cy can ini­tial­ly pro­ceed entire­ly with­out symp­toms. Symp­toms often only appear dur­ing the course of ear­ly preg­nan­cy. Typ­i­cal indi­ca­tions are one-sided low­er abdom­i­nal pain, vagi­nal bleed­ing or spot­ting, cir­cu­la­to­ry prob­lems, or an abnor­mal hCG pro­gres­sion.

Who has an increased risk for an ectopic preg­nan­cy?

The risk is increased, among oth­er things, after a pre­vi­ous ectopic preg­nan­cy, with pre­vi­ous inflam­ma­tion or oper­a­tions on the fal­lop­i­an tubes, endometrio­sis, IVF/ICSI, smok­ing, and with increas­ing age. How­ev­er, it is impor­tant to note: An ectopic preg­nan­cy can occur even with­out known risk fac­tors.

What does bleed­ing look like in an ectopic preg­nan­cy?

The bleed­ing can be very dif­fer­ent, rang­ing from light spot­ting to men­stru­a­tion-like bleed­ing. The cause can­not be reli­ably iden­ti­fied based on col­or or inten­si­ty. It can occur with or with­out accom­pa­ny­ing pain and should always be med­ical­ly eval­u­at­ed.

When does an ectopic preg­nan­cy become dan­ger­ous?

An ectopic preg­nan­cy becomes dan­ger­ous pri­mar­i­ly when inter­nal bleed­ing or a rup­ture of the fal­lop­i­an tube occurs. Warn­ing signs are sud­den severe pain, pro­nounced dizzi­ness, or cir­cu­la­to­ry prob­lems. Imme­di­ate med­ical eval­u­a­tion is nec­es­sary.

How high is the hCG in an ectopic preg­nan­cy?

There is no typ­i­cal sin­gle hCG val­ue by which an ectopic preg­nan­cy can be reli­ably iden­ti­fied. The deci­sive fac­tors are the pro­gres­sion of the hCG, the ultra­sound find­ings, and the symp­toms. An ectopic preg­nan­cy can be present even with low or falling hCG val­ues.

Can an ectopic preg­nan­cy be ruled out in the 5th week of preg­nan­cy?

Not always. In the 5th week of preg­nan­cy, it may still be too ear­ly to reli­ably assess the loca­tion of the preg­nan­cy via ultra­sound. In the case of unclear find­ings, fol­low-up checks with trans­vagi­nal ultra­sound and hCG are help­ful.

Can an ectopic preg­nan­cy regress on its own?

Yes. In the case of very ear­ly find­ings, minor symp­toms, and declin­ing hCG, an ectopic preg­nan­cy can regress on its own in some cas­es. In such instances, a close­ly mon­i­tored expec­tant man­age­ment approach is pos­si­ble.

How high is the risk of recur­rence?

After an ectopic preg­nan­cy, the risk for anoth­er ectopic preg­nan­cy is increased and lies approx­i­mate­ly in the range of 7–10%. After sev­er­al pre­vi­ous ectopic preg­nan­cies, it increas­es sig­nif­i­cant­ly fur­ther and can be about 25–30% or more after two ectopic preg­nan­cies.

Can you get preg­nant again after an ectopic preg­nan­cy?

Yes. In most cas­es, a new preg­nan­cy is pos­si­ble. Depend­ing on the his­to­ry and the desire to have chil­dren, it may be use­ful to check the fal­lop­i­an tube paten­cy, for exam­ple with a HyCoSy/HyFoSy, before a fur­ther preg­nan­cy.

Can an ectopic preg­nan­cy be present despite a nor­mal­ly ris­ing hCG?

Yes. Even an ini­tial­ly unre­mark­able hCG increase does not reli­ably rule out an ectopic preg­nan­cy. The loca­tion of the preg­nan­cy is ulti­mate­ly assessed by ultra­sound and pro­gres­sion.

Can you see an ectopic preg­nan­cy on an ultra­sound?

The diag­no­sis can often be made via trans­vagi­nal ultra­sound. How­ev­er, very ear­ly on, the loca­tion of the preg­nan­cy may still be unclear. In that case, fol­low-up checks are nec­es­sary.

Does an ectopic preg­nan­cy always have to be oper­at­ed on?

No. Depend­ing on the find­ings, expec­tant man­age­ment, treat­ment with methotrex­ate, or surgery may be con­sid­ered. The deci­sion depends on symp­toms, cir­cu­la­to­ry sta­bil­i­ty, ultra­sound find­ings, and hCG pro­gres­sion.